GC-MS Analysis of pharmaceutical drugs in blood samples using Deconvolution
GC-MS analysis of blood samples for pharmaceutical drugs using Deconvolution GC-MS Analysis of pharmaceutical drugs in blood samples using Deconvolution For over 50 years, mass spectrometers have been used as gas chromatographic (GC ) detectors . During this time, the capability and reliability of the mass spectrometer (MS), and the reproducibility of analytical data, has increased tremendously. A modern GC-MS system is capable of performing an analysis on a complex matrix of 25 compounds in less than 30 minutes. Both the qualitative and quantitative information is provided to the analyst in a short period of time. The GC-MS data system is used to process each GC peak found during the analysis and to compare the mass spectrum from each GC peak to a mass spectrum from a library of standards stored in a database. A GC-MS analysis can fail, however, when acquired spectra are “contaminated” with mass spectral peaks that arise from co-eluting compounds and ioni